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The most common type of Mesothelioma is the pleural
Mesothelioma. The pleura is a thin membrane found between the lungs and the
chest cavity. It provides a lubricated surface so that the lungs do not
chafe against the chest walls. Thus, a pleural Mesothelioma is often
referred to as a "lung" cancer.
Mesothelioma Treatment Options
Mesothelioma is a very serious disease and patients and their families
should have the support and resources they need to better deal with their
diagnosis. Course of treatment:
Traditional Treatments, Surgery - a Mesothelioma treatment used either to
remove the tumor or to alleviate pain. If the cancer is relatively
contained, surgery can be used to remove part of the lining of the chest or
abdomen.
Experimental Treatments, Gene therapy - an experimental medical intervention
that involves altering the patient’s genetic material of living cells to
fight or prevent disease.
What Are The Clinical Signs Of Mesothelioma?
Mesothelioma symptoms can be very general and therefore they are often
ignored. In most cases, symptoms for this type of cancer arise 2 to 3 months
before the cancer is found. Click on the Mesothelioma types below to learn
about their respective symptoms.
Most common type:
Pleural Mesothelioma (linning of the chest cavity)
Shorter life expectancy:
Peritoneal Mesothelioma (lining of the abdominal cavity)
Management of Mesothelioma depends largely on the staging of the tumor.
Early diagnosis and surgical intervention may lengthen life expectancy.
Depending on the age and physical condition of the patient, however, surgery
may not be a viable option. In addition to surgical options, radiation
treatment and chemotherapy may be helpful in the overall therapeutic
program. Pain management and home care are typical alternatives in the later
stages of the disease.
Occupations Commonly Associated With Mesothelioma
Asbestos has been used in association with a number of occupations. A number
of former military personnel, particularly naval, came into contact with
asbestos during their service. Massive amounts of asbestos were used in
shipbuilding and commercial construction prior to the mid-1970's. Anyone
involved with those industries is at a higher risk for developing an
asbestos-related disease, including mesothelioma. Exposure may have been
direct or indirect, lengthy or brief. The typical exposure period is
lengthy, but some persons with short but intense exposures develop
mesothelioma. Mesothelioma can also occur from non-occupational exposure, as
evidenced by manifestation of the disease in women whose exposure came from
washing the clothing of men (father, husband, son) who worked with asbestos.
A unique feature of asbestos-related injuries is the long latency period
between exposure to asbestos and the onset of the injury or disease. For
mesotheliomas, the latency period is between 15 and 50 years, or more. That
means that a person could have been exposed to asbestos 50 years ago, and
develop mesothelioma today. The average mesothelioma latency period is
approximately 35 - 40 years.
According to the National Cancer Institute, approximately 3,000 cases per
year of malignant mesothelioma are being reported in the United States, and
the incidence appears to be increasing. The disease is three times more
common in men than in women. In men, the occurrence of mesothelioma is ten
times higher in men between the ages of 60-70 as compared to men between the
ages of 30-40. Occupational exposure to asbestos over the past fifty years
in the United States is calculated to have occurred in approximately eight
million people. Asbestos Workers : Firefighters : Oil Refinery : Auto
Mechanics : Furnace Technicians : Power Plant : Blacksmith : Gas Station
Attendant : Shipyard Workers : Teachers : Masons : Woodworker.
Asbestos Related Lung Cancer
Lung cancer, or bronchial carcinoma, occurs in several forms. The most
common causes of lung cancer are smoking and asbestos. This web site has
focused on the most lethal of the lung cancers - mesothelioma. Not every
asbestos-related lung cancer, however, is a mesothelioma. Other thoracic
carcinomas, such as adenocarcinoma, are also caused by exposure to asbestos.
The connection between asbestos exposure and lung cancer was noted as early
as 1925, and confirmed over the next 70 years by many epidemiologic studies
of asbestos-exposed workers. The four main types of commercially used
asbestos, chrysotile, amosite, anthophyllite, and mixtures containing
crocidolite, have all been associated with an increased risk of lung cancer.
About one in seven people who suffer from asbestosis, a lung disease
resulting from high exposure to asbestos, eventually develop lung cancer.
There is a relationship between cigarette smoking and asbestos exposure in
causing lung cancer, such is that asbestos workers who smoke face a much
higher risk than asbestos workers who do not. According to the National
Cancer Institute, evidence suggests that asbestos-exposed workers who quit
smoking can reduce their risk of developing lung cancer by 50% within five
years of quitting.
Mesothelioma Lawyer - Your Right to Compensation
Victims of asbestos injuries are entitled to compensation from the
manufacturers of asbestos. The amount of compensation varies in each
individual case, but it is often a significant amount of money-as much as
six or seven figures. This compensation is not a windfall. If you are
suffering from an asbestos disease, you are most likely doing so through no
fault of your own. Asbestos companies covered up the fact that asbestos is
hazardous, and made billions of dollars peddling deadly products. You, the
unsuspecting user, are now paying the ultimate price.
Anyone who was injured as a result of their exposure to asbestos has a
potential legal claim against the manufacturers of asbestos products. This
can be significant for several reasons. The medical costs associated with
treating a disease such as mesothelioma can be staggering. Moreover, legal
compensation is a means by which many victims of mesothelioma provide enough
money to support a spouse or loved one, or to leave behind a legacy (for
example, to help put their grandchildren through college).
To find out if you may be entitled to legal compensation,
Mod Pathol. 2003 Aug;16(8):818-22. Abstract quote
Overexpression of KIT protein (CD117), the product of the c-kit gene, has
been shown to have important prognostic and therapeutic implications for a
number of malignant neoplasms. Previous studies have shown conflicting
results regarding the expression of c-kit in malignant mesothelioma.
To determine whether malignant mesothelioma expresses KIT,
immunohistochemistry and RT-PCR were used to analyze archived tissue from 37
cases of mesothelioma. Although a subset of mesotheliomas demonstrated
specific staining with the DAKO anti-KIT antibody, in each case staining was
nuclear. We could not detect c-kit mRNA by a sensitive RT-PCR assay, even in
cases with strong nuclear staining. Furthermore, a second anti-KIT antibody
(Cell-Marque) only demonstrated staining in a single mesothelioma case and
in none of the cases that demonstrated nuclear staining.
We conclude that immunoreactivity for KIT in mesothelioma does not represent
expression of the c-kit gene and may represent antibody cross-reaction with
nuclear proteins. Our results raise doubt about previously reported
expression of KIT in mesothelioma and consequently, the applicability of
therapeutic agents that target the kinase activity of KIT. |